邓旭坤,米雪,蔡俭,尹文仲,李游,赵碧群,蒋捷,蔡爽,吴非.竹节参总皂苷的抗肿瘤作用和毒性研究[J].中南民族大学学报自然科学版,2013,32(1):47-49
竹节参总皂苷的抗肿瘤作用和毒性研究
Anti-Tumor Activity and Toxicity of Total Saponins from Panax japonicus on H22 Tumor Bearing Mice
  
DOI:10.12130/znmdzk.20130112
中文关键词: 竹节参总皂苷  抗肿瘤  毒性作用
英文关键词: total saponins of Panax japonicus  anti-tumor activity  toxicity
基金项目:国家自然科学基金资助项目(81073147); 中南民族大学本科生“国家级创新训练项目”( GCX12019)
作者单位
邓旭坤,米雪,蔡俭,尹文仲,李游,赵碧群,蒋捷,蔡爽,吴非 中南民族大学药学院武汉430074
湖北民族学院附属医院恩施445000 
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中文摘要:
      为评价竹节参总皂苷对移植性H22荷瘤小鼠的肿瘤抑制作用和对其免疫系统的毒性,用SPF 级雄性小鼠接种肝癌H22 瘤株建立移植性肝癌H22小鼠模型,观察不同剂量的竹节参总皂苷对移植性H22荷瘤小鼠给药12d 后的抑瘤率、小鼠体重和免疫器官指数.结果表明: 40,80,160 mg /kg 竹节参总皂苷对移植性H22 荷瘤小鼠的抑制率分别为30.7%,38.6%,48%,竹节参总皂苷能增加H22荷瘤小鼠小鼠体重,但对其免疫系统明显毒性.说明竹节参总皂苷具有较显著的抗肿瘤作用,可成为抗癌新药.
英文摘要:
      To evaluate the antitumor effects of total saponins from Panax japonicus and its toxicity on immuse systems in mice transplanted with Hepatocarcinoma H22 cells,SPF male mice of Hepatocarcinoma H22 tumor model was made through H22 cells inoculation.The total saponins of 40,80,160 mg /kg of Panax japonicus were administrated to H22 tumor bearing mice to get tumor inhibitory ratio,mice weight,immune organ weight and immune index.The results showed that total saponins Panax japonicus had significant antitumor effect on the growth of H22 tumor in mice. Its inhibitory rate was 30.7%,38.6% and 48% respectively.And it could obviously increase the weight of body,but had no toxicity on immune systems.So it is concluded that total saponins of Panax japonicus may become a promising anticancer drug as it has significant antitumor effect.
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