陈连清,黄裕峰,周 泉,吴 铖,牛雄雷.氟虫腈链状烷烃酰胺化衍生物溶剂热法合成和表征[J].中南民族大学学报自然科学版,2017,(2):6-10
氟虫腈链状烷烃酰胺化衍生物溶剂热法合成和表征
Solvothermal Synthesis and Characterization of Fipronil Chain Alkane’s Aamide Derivatives
  
DOI:
中文关键词: 氟虫腈  酰胺化  溶剂热法  合成  疏水性
英文关键词: fipronil  amidation  solvothermal methods  synthesis  hydrophobic property
基金项目:国家自然科学基金资助项目(20702064, 21177161, 31402137);人事部留学人员科技活动择优资助项目(BZY13007);湖北省杰出青年基金资助项目(2013CFA034);湖北省青年英才开发计划(RCJH15001);武汉市青年科技晨光计划资助项目(201271031422)
作者单位
陈连清1,黄裕峰1,周 泉1,吴 铖1,牛雄雷2 1中南民族大学 化学与材料科学学院催化材料科学国家民委-教育部共建重点实验室 武汉430074; 2 辽宁省蚕业科学研究所凤城118100 
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中文摘要:
      为制备疏水程度和光物理性能良好的杀虫剂,经氢化钠处理,采用溶剂热法进行了一系列的链状烷烃酰氯反应,合成了10种氟虫腈链状烷烃酰胺化衍生物,其结构经红外、质谱、核磁和元素分析确证,并测试了其光物理性能和高效液相色谱保留时间.结果表明:该类化合物均具有很好的荧光性能;且随着链长及氯原子数目的增多,其保留时间、疏水性和脂溶性增加,为进一步测试氟虫腈衍生物的生物活性奠定了基础.
英文摘要:
      To develop pesticides with good hydrophobic and physical properties, 10 kinds of amide derivatives of fipronil were synthesized by treating with NaH followed by amidation with a series of amide chlorides via solvothermal method. The structures of the derivatives were confirmed by IR, mass spectrometry, NMR and elemental analysis. The photophysical properties and HPLC retention time were also examined. The results showed that these compounds had good fluorescence properties, and the retention time, hydrophobicity and lipid solubility increased with the increase of chain length and the number of chlorine atoms. This work may serve as the foundation for further testing of the biological activity of fipronil derivatives.
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