张 莉 ,王 尧.基于STM32和LABVIEW的多通道DNA合成仪控制系统的设计[J].中南民族大学学报自然科学版,2017,(4):78-83
基于STM32和LABVIEW的多通道DNA合成仪控制系统的设计
Designof Multi-ChannelDNA Synthesizer Control System Based on STM32 and LabVIEW
  
DOI:
中文关键词: 磷酸酰胺法  DNA 合成仪  STM32 微控制器
英文关键词: phosphoramidite  DNA synthesizer  STM32microcontroller
基金项目:国家自然科学基金资助项目(81101080)
作者单位
张 莉1,2 ,王 尧1,2 1 中南民族大学 生物医学工程学院武汉 430074
2 中南民族大学 检测与仪器校级工程中心武汉 430074 
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中文摘要:
      将合成 DNA 的固相亚磷酸酰胺法与自动控制技术相结合,设计了一款基于 STM32 的 96 通道寡核苷酸长链的合成仪. 该 DNA 合成仪以 STM32F103ZET6 微控制器为主控芯片,接收、 处理上位机发送的指令,并控制外围的执行单元. 人机交互界面采用 LabVIEW 开发,具有合成序列多通道输入、 工作状态监控、 与主控系统实时通信等功能. 该 DNA 合成仪控制系统可同时实现 96 个独立通道的寡核苷酸长链的合成,具有合成效率高、 操作界面友好、 操作方便等优点,完全满足中小型实验室及社区医院的碱基合成需求.
英文摘要:
      Combining solid phase phosphoramidite method of DNA synthesis with automatic control technology, a DNA synthesizer of 96 oligonucleotides long chain is designed based on STM32. The core of DNA synthesizer is STM32F103ZET6 microcontroller, who is used for receiving and processingrecinstruction from upper computer, and controlling peripheral circuit module. Based on LabVIEW development platform, application software ofupper computer is built, which has function of synthetic sequence multichannel input,working state monitoring and real-time communication with control system. The DNA synthesizer researched in this paper can achieve composition of 96 independent channel oligonucleotides long chain at the same time. It has many advantages, such as high synthetic efficiency, friendly operation interface, and easy operation mode. The DNA synthesizer can fully satisfy requirement of base composition of small and medium-sized laboratory and community hospital.
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