黄先菊,董悦,王晶,李竣,杨光忠,石召华.香连片抗细菌性痢疾相关疾病的网络药理学研究[J].中南民族大学学报自然科学版,2021,40(1):39-42
香连片抗细菌性痢疾相关疾病的网络药理学研究
Study on mechanism of Xianglian tablet anti-bacterial dysentery-related diseases based on network pharmacology
  
DOI:10.12130/znmdzk.20210107
中文关键词: 香连片  网络药理学  细菌性痢疾  靶点  通路
英文关键词: Xianglian tablet  network pharmacology  bacterial dysentery-related diseases  targets  pathway
基金项目:中医药现代化研究重点研发计划项目(SQ2017ZX09301060);湖北省技术创新专项重大项目(2018ACA126)
作者单位
黄先菊 中南民族大学药学院武汉430074 
董悦 中南民族大学药学院武汉430075 
王晶 中南民族大学药学院武汉430076 
李竣 中南民族大学药学院武汉430077 
杨光忠 中南民族大学药学院武汉430078 
石召华 武汉爱民制药股份有限公司武汉430070 
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中文摘要:
      目的: 基于网络药理学方法探讨香连片抗细菌性痢疾相关疾病的作用机制.方法:通过中药系统药理学分析平台(TCMSP)筛选香连片的主要活性成分;通过TCMSP及Swiss Target Prediction数据库查找筛选其活性成分的对应靶点.收集有关细菌性痢疾相关疾病的靶点,映射至香连片活性成分靶点基因,构建活性成分-靶点网络,构建共同靶点蛋白相互作用网络(PPI).将共同靶基因进行GO功能富集与 KEGG通路富集分析.结果:从香连片中筛选出42个活性成分,19个与细菌性痢疾相关疾病的作用靶点;GO功能富集筛选得到生物学过程相关条目12条、分子功能相关条目5条及细胞组分相关条目6条;KEGG通路富集筛选得到8条相关通路,涉及钙信号通路、癌症通路、跨膜受体蛋白酪氨酸激酶信号通路等.结论:香连片可能通过钙信号通路、癌症通路、跨膜受体蛋白酪氨酸激酶信号等,对细胞增殖、凋亡、炎症反应等过程产生影响而抗细菌性痢疾相关疾病的作用,此外预测中表明其作用还涉及多条癌症通路,可为其预防癌症研究提供一定依据.
英文摘要:
      Objective:To explore the mechanism of Xianglian tablet anti-bacterial dysentery-related diseases based on network pharmacological methods. Methods: The corresponding targets of the active ingredients of the Xianglian tablet were screened by the Traditional Chinese Medicine System Pharmacology Database and Analysis Platform(TCMSP) and Swiss Target Prediction. The targets of bacterial dysentery-related diseases were collected, mapped to the target gene of the active ingredient of Xianglian tablet, and the active ingredients-target network were constructed. Interactive protein-protein interaction network(PPI) were constructed. The common target genes were subjected to gene ontology(GO) enrichment and Kyoto encyclopedia of genes and genomes(KEGG) pathway enrichment analyses. Results: 42 active ingredients and 19 targets related to anti-bacterial dysentery-related diseases were screened out. 12 items related to biological process, 5 items related to molecular function and 6 items related to cell components were screened out by GO function enrichment; 8pathways related to cancer pathway and osteoclast differentiation signal were screened out by KEGG pathway enrichment, etc. Conclusion: Xianglian tablet may play a role in the treatment of bacterial dysentery-related diseases through the influence of Calcium signaling pathway, Pathways in cancer and other effectson cell proliferation, apoptosis, inflammatory response.In addition, multiple cancer pathways are involved in the prediction, which may provide directions for cancer prevention research.
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