胡晓允,王雪茹,单自兴.KH2PO4催化Hantzsch反应合成4H-色烯衍生物拆分头孢氨苄对映体[J].中南民族大学学报自然科学版,2014,(1):7-10
KH2PO4催化Hantzsch反应合成4H-色烯衍生物拆分头孢氨苄对映体
Synthesis of 4H-chromene Derivatives via Hantzsch Reaction Catalyzed by KH2PO4
  
DOI:
中文关键词: Hantzsch 反应  4H-色烯衍生物  磷酸二氢钾
英文关键词: Hantzsch reaction  4H-chromene derivatives  Potassium dihydrogen phosphate
基金项目:国家自然科学基金资助项目(21302233),湖北省自然科学基金资助项目(2012FFB07410)
作者单位
胡晓允1,王雪茹1,单自兴2 1 中南民族大学 化学与材料科学学院 武汉 4300742 武汉大学化学与分子科学学院武汉430072 
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中文摘要:
      4H-色烯衍生物作为一种便宜易得的酸性无机盐,可有效催化Hantzsch 反应合成4H-色烯衍生物.在优化条件下,4H-色烯衍生物可通过简单的过滤操作直接分离得到,含有催化剂的滤液则可以继续催化该反应,循环催化3次而不失活.这为4H-色烯衍生物的合成提供了一种实用且绿色化程度较高的方法,有潜在的工业化应用前景.
英文摘要:
      4H-chromene derivatives could be efficiently synthesized via Hantzsch reaction catalyzed by potassium dihydrogen phosphate, which is an inexpensive acidic inorganic salt. Under the optimized conditions, 4H-chromene derivatives could be directly separated in high yields via simple filtration. The filtrate containing potassium dihydrogen phosphate could be directly reused to catalyze this reaction for three times without appreciable loss of catalytic activity. It provided a practical and environmentally friendly method for the synthesis of 4H-chromene derivatives and had a good potential in industrial application.
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