周冬梅,汤云仙,冯冠男,杨如,余玲.CA125、CA199及HE4联合检测对卵巢子宫内膜异位囊肿破裂的诊断[J].中南民族大学学报自然科学版,2022,41(5):542-546
CA125、CA199及HE4联合检测对卵巢子宫内膜异位囊肿破裂的诊断
Combined detection of CA125, CA199 and HE4 for the diagnosis of ruptured ovarian endometriotic cysts
  
DOI:10.12130/znmdzk.20220505
中文关键词: 癌抗原125  癌抗原199  人附睾蛋白4  卵巢子宫内膜异位囊肿破裂  诊断
英文关键词: cancer antigen 125  cancer antigen 199  human epididymis protein 4  ruptured ovarian endometriotic cyst  diagnostic value
基金项目:苏州市“科教兴卫”青年科技项目(KJXW2016028)
作者单位
周冬梅 南京医科大学附属苏州医院 妇产科苏州 215000 
汤云仙 南京医科大学附属苏州医院 妇产科苏州 215000 
冯冠男 南京医科大学附属苏州医院 妇产科苏州 215000 
杨如 南京医科大学附属苏州医院 妇产科苏州 215000 
余玲 南京医科大学附属苏州医院 妇产科苏州 215000 
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中文摘要:
      目的:探讨癌抗原125(CA-125)、癌抗原199(CAl99)及人附睾蛋白4(HE4)联合检测对卵巢子宫内膜异位囊肿破裂诊断价值.方法:选择2010年1月至2020年5月在南京医科大学附属苏州医院进行治疗的卵巢子宫内膜异位囊肿破裂患者67例为观察组,以年龄(±5岁)进行1∶1配比选择同期治疗的卵巢子宫内膜异位囊肿未破裂患者67例为对照组.收集两组患者人口学特征、临床资料及实验室检查结果.结果:两组患者年龄、BMI指数、囊肿部位、手术方式、ASRM分期比较差异无统计学意义(P>0.05),观察组患者囊肿直径大于对照组(P<0.05).观察组患者CA125、CA199及HE4水平均明显高于对照组(P<0.05).不同囊肿部位、ASRM分期观察组患者CA125、CA199及HE4检测结果差异均无统计学意义(P>0.05).ROC分析结果显示:血清CA125、CA199及HE4对卵巢子宫内膜异位囊肿破裂诊断的截断值分别为113.82 U/mL、104.29 U/mL及159.03 pmol/L;曲线下面积(AUC)分别为0.806、0.759及0.528.三者联合诊断(指血清CA125、CA199或HE4联合检测时其中1个指标高于截断值即判断为卵巢子宫内膜异位囊肿破裂)的AUC为0.905,其诊断效能高于各指标单独(P<0.05).结论:卵巢子宫内膜异位囊肿破裂诊患者血清CA125、CA199及HE4水平均高于未破裂者,血清CA125、CA199及HE4均可作为卵巢子宫内膜异位囊肿破裂的诊断指标,联合检测可提高诊断效能.
英文摘要:
      Objective:To evaluate the diagnostic value of combined detection of cancer antigen 125 (CA125), cancer antigen 199 (CA199) and human epididymal protein 4 (HE4) forruptured ovarian endometriotic OEC. Methods:67 patients with ruptured ovarian endometriosis cyst who were treated in Suzhou Hospital of Nanjing Medical University from January 2010 to May 2020 were selected as the observation group, and 67 patients with unruptured ovarian endometriosis cyst treated in the same period were selected as the control group with a 1∶1 ratio by age (±5 years). The demographic characteristics, clinical data and laboratory test results of the two groups of patients were collected. Results:There were no significant differences in age, BMI index, cyst location, surgical method, and ASRM staging between the two groups (P>0.05). The diameter of the cyst in the observation group was larger than that in the control group (P<0.05). The levels of CA125, CA199 and HE4 in the observation group were significantly higher than those in the control group (P<0.05).There was no significant difference in the detection results of CA125, CA199 and HE4 in patients with different cyst sites and ASRM staging for the observation groups (P>0.05). ROC analysis showed that the cut-off values of serum CA125, CA199 and HE4 were 113.82 U/mL, 104.29 U/mL and 159.03 pmol/L, respectively; the area under curve (AUC) was 0.806, 0.759 and 0.528, respectively. When serum CA125, CA199 or HE4 were detected jointly (i.e., rupture of ovarian endometriotic cyst would be positively confirmed when one of the indicators of serum CA125, CA199 or HE4 was higher than the cut-off value), the AUC was 0.905, and the diagnostic efficiency was higher than using one of the three indexes alone (P<0.05). Conclusion:The levels of serum CA125, CA199 and HE4 in patients with rupture of ovarian endometriosis cyst were higher than those in patients with unruptured cyst. Serum CA125, CA199 and HE4 can be used as diagnostic indicators of ovarian endometriosis cyst rupture, and combined detection can improve the diagnostic efficiency.
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