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| 光甘草定-烟酰胺纳米乳的制备与抗氧化效果 |
| Preparation and antioxidant efficacy of glabridin-nicotinamide loaded nanoemulsion |
| 投稿时间：2022-01-10 修订日期：2022-03-08 |
| DOI： |
| 中文关键词: 纳米乳 伪三元相图 Box-Behnken响应面设计法 光甘草定 烟酰胺 |
| 英文关键词: nanoemulsion pseudo-ternary phase diagram Box-Behnken response surface design method glabridin nicotinamide |
| 基金项目: |
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| 中文摘要: |
| 摘 要 制备光甘草定-烟酰胺纳米乳（G-N-NE）并初步评价其抗氧化效果。采用相转变乳化高压均质法制备G-N-NE，借助伪三元相图法联合Box-Behnken响应面设计法（BBD-RSM）筛选获得G-N-NE最佳处方并进行验证，通过DPPH·自由基清除率初步评价G-N-NE的抗氧化效果。结果表明：G-N-NE最佳处方为辛酸癸酸三酰甘油/肉豆蔻异丙酯/吐温80/无水乙醇/光甘草定/0.10%烟酰胺水溶液（3.97 : 1.99 : 18. 54 : 4.64 : 0.10 : 70.76），粒径为(88.41 ± 0.19) nm，多分散指数PDI为(0.253 ± 0.01)，Zeta电位为(-7.79 ± 0.12) mv，烟酰胺载药量与包封率分别为(5.42 ± 0.04)%与(93.01 ± 0.23)%，光甘草定的载药量与包封率分别为(6.82 ± 0.06)%与(97.01 ± 0.06)%，相比光甘草定-烟酰胺溶液和光甘草定纳米乳，G-N-NE对DPPH·自由基有更好的清除效果,说明G-N-NE性质稳定、包封率高，具有良好的抗氧化效果。 |
| 英文摘要: |
| To prepare glabridin-nicotinamide loaded nanoemulsion (G-N-NE) and preliminarily evaluate its antioxidant effect. G-N-NE was prepared by phase transition emulsification high-pressure homogenization method, and its optimized prescription was obtained and verified by the pseudo-ternary phase diagram method combined with Box-Behnken response surface design method (BBD-RSM). The DPPH scavenging rate was used to preliminarily evaluate the antioxidant efficacy of G-N-NE. The results indicated that the optimized prescription of G-N-NE was caprylic acid capric acid triacylglycerol/ myristyl isopropyl ester/ Tween 80/ absolute ethanol/ glycyrrhizin/0.10% nicotinamide aqueous solution (3.97 : 1.99 : 18. 54 : 4.64 : 0.10 : 28.24), the particle size was (88.41 ± 0.19) nm, the polydispersity index (PDI) was 0.253 ± 0.01, the zeta potential was (-7.79 ± 0.12) mv, the drug loading and encapsulation efficiency of nicotinamide were (5.42 ± 0.04) % and (93.01 ± 0.23) %, the drug loading and encapsulation efficiency of glabridin were (6.82 ± 0.06) % and (97.01 ± 0.06) %, respectively. Compared with glabridin -nicotinamide solution and glabridin nanoemulsion, G-N-NE had a better scavenging effect on DPPH·free radicals, which indicated that G-N-NE has stable properties, high encapsulation efficiency and satisfying antioxidant efficacy. |
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